How RINVOQ Works video transcript

Music track throughout.

 

TEXT ON SCREEN: ULCERATIVE COLITIS

 

ANNOUNCER VOICE OVER (VO): Ulcerative colitis,

 

TEXT ON SCREEN: UC

 

AVO: also known as UC,

 

TEXT ON SCREEN: UC

 

A condition where chronic inflammation damages your colon

 

AVO: is a condition where chronic inflammation damages your colon,

 

TEXT ON SCREEN: Sudden accidents

Increased bathroom trips

Blood in your stool

Gut pain

 

AVO: which can lead to symptoms like sudden accidents, increased trips to the bathroom, blood in your stool, and gut pain.

 

AVO: You may be used to thinking of inflammation as redness or swelling. When you’re healthy, inflammation is one of your body’s defenses against things that can hurt you or make you sick.

 

AVO: But, there is such a thing as too much inflammation. That’s the case with UC, where the inner lining of your colon gets inflamed even when your body doesn’t need the protection. Inflammation can build up, causing more damage over time.

 

TEXT ON SCREEN: WITH UC,
you may be wondering why your immune system doesn’t know when to stop making inflammation.

 

AVO: With UC, you may be wondering why your immune system doesn’t know when to stop making inflammation. Let’s take a look.

 

AVO: Your body has many natural pathways involved in inflammation. They pass along information to help your immune system figure out when and where inflammation should happen. One of those pathways involves proteins known as Janus kinase, or JAK proteins.

 

TEXT ON SCREEN: JAK

 

AVO: With UC, some JAK proteins receive too many signals, causing your immune system to create too much inflammation and start to damage the colon.

 

TEXT ON SCREEN:

 

A ONCE-DAILY PILL

for adults with moderate to severe UC in whom TNF blockers did not work well

Pill not actual size

Please see Important Safety Information in video and on this web page.
Please see link for the full Prescribing Information, including the Medication Guide.

 

AVO: That’s where RINVOQ, a once-daily pill, can help. RINVOQ is a prescription medicine used to treat adults with moderate to severe ulcerative colitis in whom TNF blockers did not work well.

 

TEXT ON SCREEN: JAK
RINVOQ

 

AVO: RINVOQ stops the activity of some JAK proteins. That means when you have too much inflammation, RINVOQ can help regulate your overactive immune system. 

 

AVO: RINVOQ is a once-daily pill that travels through the bloodstream, helping to reduce inflammation and give your colon lining the chance to repair from the buildup of damage.

 

TEXT ON SCREEN: IN CLINICAL STUDIES, RINVOQ WAS PROVEN TO HELP DELIVER:

 

Rapid symptom relief as early as 2 weeks*

*Based on the frequency of bowel movements and the amount of bloody stools.

Remission in 8 weeks, with many people in lasting remission even at 1 year

Visible improvement of the colon lining

 

AVO: In clinical studies RINVOQ was proven to help deliver rapid symptom relief, lasting remission, and visible improvement of the colon lining.

 

TEXT ON SCREEN:
For adults with moderate to severe UC in whom TNF blockers did not work well
Ask your gastroenterologist if RINVOQ is right for you

 

US-RNQG-220377

 

AVO: Ask your gastroenterologist if RINVOQ is right for you.

 

AVO and TEXT ON SCREEN:

 

SAFETY CONSIDERATIONS

RINVOQ may cause serious side effects, including:

  • Serious infections. RINVOQ can lower your ability to fight infections. Serious infections, some fatal, occurred while taking RINVOQ, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
  • Increased risk of death in people 50 years and older with at least 1 heart disease risk factor.
  • Cancer and immune system problems. RINVOQ may increase your risk of certain cancers, including lymphoma and skin cancer. Current or past smokers are at higher risk for lymphoma and lung cancer.
  • Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50 years and older with at least 1 heart disease risk factor, especially in current or past smokers.
  • Blood clots, some fatal, in the veins of the legs or lungs and arteries. This occurred more often in people 50 years and older with at least 1 heart disease risk factor.
  • Serious allergic reactions. Do not take if allergic to RINVOQ or any of its ingredients.
  • Tears in the stomach or intestines and changes in certain laboratory test results.

TEXT ON SCREEN:
Please see additional Important Safety Information on this page.